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Enhanced antitumor activity of adriamycin in combination with allopurinol
Cancer Letters
|August 1, 1983
Abstract:
Xanthine oxidase reduction of adriamycin (Am) and daunorubicin (Dm) to their respective 7-deoxy aglycones is inhibited by allopurinol. Administered to DBA/2 mice with L1210 leukemia, allopurinol (60 mg/kg per day X 3) enhances the antitumor activity of adriamycin.
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