Insemination of husband's semen with and without the addition of caffeine

Four hundred cervicovaginal artificial inseminations using husband's semen were carried out for a variety of clinical indications. Before insemination, to one-half of the samples caffeine was added to a final concentration of 6 mM. Although the motility of the spermatozoa was enhanced in each case, no pregnancies were achieved. Of the four pregnancies in the series, only one could be attributed to artificial insemination.