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[Goiter in childhood].

G C Mussa

    La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This review differentiates pediatric goitre conditions, noting a decline in endemic goitres due to iodine deficiency. It highlights genetic hormonal synthesis defects and immune-related thyroid diseases like Hashimoto thyroiditis and Grave's disease.

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    Area of Science:

    • Pediatric Endocrinology
    • Thyroidology
    • Genetics

    Context:

    • Goitre in children presents diverse clinical conditions, including euthyroidism, hypothyroidism, and hyperthyroidism.
    • Etiopathogenesis reveals a decrease in endemic goitres linked to dietary iodide deficiency.
    • Genetic factors and immune system interactions are increasingly recognized causes.

    Purpose:

    • To review and differentiate the clinical presentations of goitre in pediatric populations.
    • To explore the changing etiopathogenesis of goitre, emphasizing genetic and autoimmune factors.
    • To discuss the spectrum of thyroid dysfunction in children, from hormonal synthesis defects to peripheral resistance.

    Summary:

    • The review differentiates pediatric goitre into euthyroid, hypothyroid, and hyperthyroid states.

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  • It notes a reduction in endemic goitres due to improved iodine intake, with a rise in genetically transmitted hormonal synthesis defects.
  • Autoimmune thyroid diseases, such as Hashimoto thyroiditis and Grave's disease, and rare familial resistance to thyroid hormones are also discussed.

    • Impact:

    • Provides a comprehensive overview for clinicians managing pediatric thyroid disorders.
    • Highlights the shift in goitre etiology towards genetic and autoimmune conditions.
    • Enhances understanding of the diverse causes and clinical manifestations of goitre in children.