Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Analysis of eustachian surfactant and its function as a release agent.

B A Hills

    Archives of Otolaryngology (Chicago, Ill. : 1960)
    |January 1, 1984
    PubMed
    Summary

    Eustachian tube surfactants, particularly phosphatidylethanolamine, reduce adhesion by acting as release agents. An imbalance between proteins and these surfactants may contribute to serous otitis media.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    'Free' surfactant in gastric aspirates and bronchoalveolar lavage in children with and without reflux oesophagitis.

    Internal medicine journal·2006
    Same author

    Comparison of surfactant lipids between pleural and pulmonary lining fluids.

    Pulmonary pharmacology & therapeutics·2005
    Same author

    The synovial response to exogenous phospholipid (synovial surfactant) injected into the equine radiocarpal joint compared with that to prilocaine, hyaluronan and propylene glycol.

    New Zealand veterinary journal·2005
    Same author

    Surface-active phospholipid (surfactant) in equine tendon and tendon sheath fluid.

    New Zealand veterinary journal·2005
    Same author

    Biomechanical responses of normal and delipidized articular cartilage subjected to varying rates of loading.

    Connective tissue research·2005
    Same author

    Consolidation responses of delipidized articular cartilage.

    Clinical biomechanics (Bristol, Avon)·2004

    Area of Science:

    • Biochemistry
    • Otolaryngology
    • Surface Chemistry

    Background:

    • The eustachian tube's function is crucial for middle ear health.
    • Phospholipids play diverse biological roles, including surface activity.
    • Serous otitis media involves fluid accumulation in the middle ear.

    Purpose of the Study:

    • To identify and characterize phospholipids in the eustachian tube.
    • To investigate the surface activity and adhesive properties of eustachian tube extracts.
    • To explore the potential role of eustachian tube surfactants in middle ear effusions and otitis.

    Main Methods:

    • Thin-layer chromatography was used for phospholipid identification.
    • Surface tension measurements assessed surfactant activity.
    • Adhesion tests evaluated the release agent properties of adsorbed monolayers.

    Main Results:

    • Phospholipids, including phosphatidylcholine and phosphatidylethanolamine, were detected in eustachian tubes.
    • Eustachian tube extracts exhibited surface activity and adsorbed to solids.
    • Adsorbed eustachian surfactants reduced albumin-mediated adhesion by up to 94%.

    Conclusions:

    • Eustachian tube surfactants possess potent release agent capabilities.
    • An adverse protein-surfactant ratio may be implicated in the pathogenesis of serous otitis.
    • Further research into the adhesion:release ratio in middle ear effusions is warranted.

    Related Experiment Videos