Lack of effect of indomethacin on gastric emptying in old men

Indomethacin, widely prescribed in the elderly, has a potential for affecting concomitant absorption of other drugs by changing gastric emptying time. A study of basal and post-indomethacin gastric emptying times (GET) in ten patients aged 69-86 (mean age 77) shows no significant change in GET after indomethacin administration. The data suggest that drugs whose potencies can be altered by gastric retention may be taken concomitantly with indomethacin.