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Platelet 5-hydroxytryptamine release and aggregation promoted by cotton bracts tannin
The Journal of Laboratory and Clinical Medicine
|January 1, 1984
Summary
Cotton bract extract (CBE) and its component tannin induce platelet secretion and aggregation. This may explain pulmonary symptoms like byssinosis, highlighting tannin
Area of Science:
- Biochemistry
- Hematology
- Toxicology
Background:
- Byssinosis is a respiratory disease linked to cotton dust exposure.
- Platelet activation plays a role in inflammatory and vascular responses.
Purpose of the Study:
- To investigate the effects of cotton bract extract (CBE) on platelet function.
- To identify the component in CBE responsible for platelet activation.
Main Methods:
- Washed human and bovine platelets were used to assess secretion and aggregation.
- Platelet 5-hydroxytryptamine (5-HT) release was measured.
- Platelet aggregation was induced by CBE and its fractions.
Main Results:
- CBE dose-dependently induced significant release of platelet 5-HT (75-90%) without causing cell lysis.
- Indomethacin, 2-deoxyglucose, and KCN did not inhibit this secretion.
- Tannin, a condensed polyphenol, was identified as the active secretagogue and also induced platelet aggregation.
Conclusions:
- Tannin in CBE is a potent inducer of platelet 5-HT secretion and aggregation.
- These platelet effects may contribute to the pathogenesis of byssinosis.