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A new oncogene, c-raf, is located on mouse chromosome 6
Journal of Virology
|January 1, 1984
Summary
The acute transforming virus 3611-MSV contains viral-raf (v-raf) sequences. Mouse DNA has a homologous c-raf oncogene located on chromosome 6.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- The acute transforming virus 3611-MSV harbors viral-raf (v-raf) sequences.
- Cellular DNA in mice contains a single-copy sequence homologous to this oncogene, termed c-raf.
Purpose of the Study:
- To investigate the genetic location of the mouse c-raf oncogene.
Main Methods:
- Southern blot analysis was performed on hamster-mouse somatic cell hybrid DNAs.
Main Results:
- The mouse c-raf sequence was identified and confirmed to be located on chromosome 6.
Conclusions:
- The c-raf oncogene in mice is situated on chromosome 6, providing a key genetic marker for further research into its function and potential role in oncogenesis.