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Related Experiment Videos

Pulmonary infiltrates associated with naproxen.

A J Buscaglia, F E Cowden, H Brill

    JAMA
    |January 6, 1984
    PubMed
    Summary

    Naproxen sodium can cause pulmonary infiltrates and flu-like symptoms in some individuals. These reactions, characterized by eosinophilia, typically resolve after discontinuing the medication.

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    Area of Science:

    • Pulmonology
    • Rheumatology
    • Clinical Pharmacology

    Background:

    • Naproxen sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID).
    • NSAIDs can rarely cause idiosyncratic reactions.
    • Pulmonary complications associated with NSAIDs are uncommon.

    Observation:

    • Three middle-aged women presented with new-onset pulmonary infiltrates.
    • Patients experienced symptoms including weakness, fatigue, cough, and low-grade fever.
    • Blood and/or sputum analysis revealed eosinophilia in all cases.

    Findings:

    • Symptoms and pulmonary infiltrates resolved after naproxen sodium withdrawal in two patients.
    • One patient required corticosteroid (prednisone) treatment for symptom resolution.
    • The clinical presentation suggests a hypersensitivity reaction to naproxen sodium.

    Implications:

    • This case series highlights a potential hypersensitivity pneumonitis associated with naproxen sodium.
    • Clinicians should consider NSAID-induced hypersensitivity in patients with unexplained pulmonary infiltrates and eosinophilia.
    • Early recognition and drug withdrawal are crucial for managing this adverse drug reaction.

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