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Related Experiment Videos

Variant angina induced by alcohol ingestion.

A Takizawa, H Yasue, S Omote

    American Heart Journal
    |January 1, 1984
    PubMed
    Summary

    Alcohol consumption can trigger anginal attacks in patients with variant angina. This study found a definite link between alcohol intake and angina episodes in a significant number of patients, suggesting a role in coronary artery spasm.

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    Area of Science:

    • Cardiology
    • Gastroenterology
    • Pharmacology

    Background:

    • Variant angina is a condition characterized by chest pain due to coronary artery spasms.
    • The role of specific triggers, such as alcohol, in variant angina requires further elucidation.

    Purpose of the Study:

    • To investigate the relationship between alcohol ingestion and the occurrence of anginal attacks in patients with variant angina.
    • To determine if alcohol can induce coronary artery spasm.

    Main Methods:

    • Prospective study involving alcohol administration to 15 patients with variant angina to provoke attacks.
    • Retrospective analysis of medical histories from 101 patients with variant angina focusing on alcohol consumption patterns.
    • Monitoring of time lag between alcohol ingestion and anginal attacks.

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    Main Results:

    • Anginal attacks were reproducibly induced by alcohol in 7 out of 15 patients during hospitalization.
    • A significant percentage of patients (26.8%) with variant angina reported a clear link between alcohol consumption and anginal episodes.
    • The latency period between alcohol intake and angina varied (1.5-12 hours) but was consistent within individuals.

    Conclusions:

    • Alcohol can precipitate anginal attacks in a notable proportion of patients suffering from variant angina.
    • Alcohol-induced coronary artery spasm is a plausible mechanism underlying these anginal attacks.