Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vancomycin dosage in pediatrics reconsidered.

G Alpert, J M Campos, M C Harris

    American Journal of Diseases of Children (1960)
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    WITHDRAWN: PARCERIA BASEADA EM VALOR: A JORNADA DO PACIENTE DE MIELOMA MÚLTIPLO E O USO DE TECNOLOGIA EM SAÚDE.

    Hematology, transfusion and cell therapy·2022
    Same author

    The application of Bonelike® Poro as a synthetic bone substitute for the management of critical-sized bone defects - A comparative approach to the autograft technique - A preliminary study.

    Bone reports·2021
    Same author

    #SoMe4PedSurg: social media, education, and digital innovation in pediatric surgery.

    Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica·2021
    Same author

    Author Correction: Biological parameters, life table and thermal requirements of Thaumastocoris peregrinus (Heteroptera: Thaumastocoridae) at different temperatures.

    Scientific reports·2020
    Same author

    Biological parameters, life table and thermal requirements of Thaumastocoris peregrinus (Heteroptera: Thaumastocoridae) at different temperatures.

    Scientific reports·2019
    Same author

    Characterization and application of a biosurfactant isolated from Candida utilis in salad dressings.

    Biodegradation·2019
    Same journal

    Nonsteroidal anti-inflammatory drugs and gastrointestinal injury in children.

    American journal of diseases of children (1960)·1993
    Same journal

    Picture of the month. Cutaneous leishmaniasis.

    American journal of diseases of children (1960)·1993
    Same journal

    Pathological case of the month. Wells' syndrome.

    American journal of diseases of children (1960)·1993
    Same journal

    Radiological case of the month. Proteus syndrome: benign angiolipomatous tumor with intraspinal extension.

    American journal of diseases of children (1960)·1993
    Same journal

    Applicability of the Greulich and Pyle skeletal age standards to black and white children of today.

    American journal of diseases of children (1960)·1993
    Same journal

    Maltreatment of children born to cocaine-dependent mothers.

    American journal of diseases of children (1960)·1993
    See all related articles

    Vancomycin hydrochloride dosing in children shows significant variability, leading to potentially toxic levels in some young patients. Current recommendations may not ensure consistent therapeutic vancomycin concentrations in pediatric populations.

    Area of Science:

    • Pediatric Pharmacology
    • Infectious Disease Pharmacokinetics
    • Clinical Pharmacy

    Background:

    • Vancomycin is a critical antibiotic for treating serious Gram-positive bacterial infections in children.
    • Optimizing vancomycin dosing is essential to balance efficacy and minimize toxicity, especially in vulnerable pediatric populations.

    Purpose of the Study:

    • To evaluate the pharmacokinetic variability of vancomycin hydrochloride in a pediatric cohort.
    • To assess the adequacy of current dosing guidelines in achieving therapeutic vancomycin levels in children of different age groups.

    Main Methods:

    • A prospective study involving 44 children aged 10 days to 10 years receiving vancomycin.
    • Therapeutic drug monitoring of vancomycin peak and trough serum concentrations.
    • Analysis of vancomycin levels in relation to age and prescribed dosage regimens.

    Related Experiment Videos

    Main Results:

    • Significant inter-patient variability in vancomycin levels was observed across similar age groups and dosages.
    • High percentages of elevated peak (70%, 39%, 30%) and trough (53%, 50%, 23%) vancomycin levels were noted in neonates, infants, and older children, respectively.
    • Eight patients exhibited potentially toxic vancomycin concentrations.

    Conclusions:

    • Current vancomycin dosing recommendations may lead to suboptimal or toxic drug levels in pediatric patients.
    • Age-specific pharmacokinetic differences necessitate careful monitoring and potential dose adjustments in children.
    • Further research is warranted to refine vancomycin dosing strategies for improved pediatric outcomes.