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Experimental ocular toxocariasis: a mouse model.

S Y Ghafoor, H V Smith, W R Lee

    The British Journal of Ophthalmology
    |February 1, 1984
    PubMed
    Summary
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    Toxocara canis infection in mice eyes causes inflammation. Even without larvae, secreted antigens can trigger a persistent granulomatous response, indicating a potential mechanism for ocular toxocariasis.

    Area of Science:

    • Ophthalmology
    • Parasitology
    • Immunology

    Background:

    • Ocular toxocariasis is a significant cause of vision loss.
    • The role of Toxocara canis larval antigens in persistent ocular inflammation is not fully understood.

    Purpose of the Study:

    • To investigate the ocular inflammatory response to Toxocara canis infection in mice.
    • To determine if larval antigens alone can elicit an inflammatory reaction.

    Main Methods:

    • Male C57 black mice were infected with Toxocara canis eggs.
    • Ocular tissues were examined using conventional microscopy at sequential time points (6-63 days post-infection).
    • Histological characteristics of the inflammatory response were documented.

    Main Results:

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    • Inflammatory changes were observed in 29 out of 49 infected eyes, independent of larval presence.
    • In 20 eyes, larvae were found in the retina, retinal vessels, or subretinal space.
    • The inflammatory response evolved from polymorphonuclear to granulomatous by day 13.

    Conclusions:

    • Toxocara canis infection induces significant ocular inflammation in mice.
    • Secreted larval antigens may propagate inflammation even in the absence of intact or fragmented larvae.
    • This suggests a potential mechanism for chronic ocular inflammation in toxocariasis.