[Effect of high-density lipoproteins on cholesterol biosynthesis in rat liver]

Under the conditions of long-term intravenous perfusion to recipient rats of a solution of rat high density lipoproteins at a concentration exceeding the physiological one and in the absence of stressor components, the animals' liver tissue manifested a significant decrease in free cholesterol. Since the rate of the label incorporation in liver cholesterol increased concurrently, it is suggested that a considerable rise in the content of high density lipoproteins in the blood of rats under the physiological conditions may lead to a fall in liver cholesterol because of which the developing hypocholesterolemia gives rise to the activation of the synthesis of this sterol.