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Tuberculosis and nonsteroidal anti-inflammatory drugs
Canadian Medical Association Journal
|February 1, 1984
Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs) may be associated with tuberculosis reactivation. This case-control study found a significant relation, but further research is needed to confirm the direct link. NSAIDs can mask infections.
Area of Science:
- Infectious Diseases
- Pharmacology
- Pulmonology
Background:
- Case reports from 1980 and 1982 suggested a link between nonsteroidal anti-inflammatory drug (NSAID) use and tuberculosis (TB) reactivation.
- NSAIDs are potent anti-inflammatory agents with potential to influence infection processes.
Purpose of the Study:
- To investigate the hypothesis that NSAID use is associated with reactivation of pulmonary tuberculosis.
- To determine the relationship between NSAID usage and TB reactivation.
Main Methods:
- A case-control study design was employed.
- Data were collected from 38 patients with TB reactivation.
- Each patient was matched with a control from the same medical practice based on age, sex, race, and duration of practice enrollment.
Main Results:
- A statistically significant association was identified between the reactivation of tuberculosis and the use of NSAIDs.
- The findings suggest a potential link requiring further investigation.
Conclusions:
- The study indicates a significant relationship between NSAID use and tuberculosis reactivation.
- Further research is necessary to elucidate the nature of this association (direct, indirect, or due to an unknown factor).
- Clinicians should consider the potential for NSAIDs to activate, spread, or mask infections like tuberculosis.