Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regional cancer chemotherapy.

W D Ensminger, J W Gyves

    Cancer Treatment Reports
    |January 1, 1984
    PubMed
    Summary

    Regional cancer chemotherapy delivers higher drug doses directly to tumors, improving response rates compared to systemic treatments. Advances in drug delivery devices and imaging enhance the safety and efficacy of these localized cancer therapies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Selective radioprotection of hepatocytes by systemic and portal vein infusions of amifostine in a rat liver tumor model.

    International journal of radiation oncology, biology, physics·2001
    Same author

    Interaction between gemcitabine and mitomycin-C in vitro.

    Cancer chemotherapy and pharmacology·2000
    Same author

    Treatment of intrahepatic cancers with radiation doses based on a normal tissue complication probability model.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology·1998
    Same author

    Regional pharmacokinetics of 5-fluorouracil in dogs: role of the liver, gastrointestinal tract, and lungs.

    Cancer research·1998
    Same author

    A phase I trial of hepatic arterial bromodeoxyuridine and conformal radiation therapy for patients with primary hepatobiliary cancers or colorectal liver metastases.

    International journal of radiation oncology, biology, physics·1997
    Same author

    Long-term results of hepatic artery fluorodeoxyuridine and conformal radiation therapy for primary hepatobiliary cancers.

    International journal of radiation oncology, biology, physics·1997

    Area of Science:

    • Oncology
    • Pharmacology
    • Medical Devices

    Background:

    • Regional cancer chemotherapy offers a targeted approach to exploit dose-response effects for confined tumors.
    • This method involves third-space (intracavitary) and intra-arterial delivery, showing higher response rates than systemic therapies.
    • Recent interest is driven by improved outcomes and a better understanding of pharmacokinetic principles.

    Purpose of the Study:

    • To review the principles and advancements in regional cancer chemotherapy.
    • To highlight the benefits of regional drug delivery over systemic administration.
    • To discuss the role of new technologies in improving regional therapy efficacy and safety.

    Main Methods:

    • Review of pharmacokinetic principles relevant to regional drug delivery.
    • Discussion of drug delivery methods, including third-space and intra-arterial treatments.
    • Evaluation of the impact of totally implanted devices and nuclear medicine scanning on regional therapy.

    Main Results:

    • Regional chemotherapy demonstrates significantly higher response rates compared to systemic therapies.
    • Drug delivery advantage is linked to total-body drug clearance, egress rate, and regional blood flow.
    • Implanted devices enhance reliability, safety, and convenience; nuclear medicine aids distribution assessment.

    Conclusions:

    • Regional chemotherapy offers a potent strategy for localized tumor control.
    • Optimized drug delivery and pharmacokinetic understanding are crucial for maximizing efficacy.
    • Future research should focus on developing more potent regional therapies and validating them through clinical trials.

    Related Experiment Videos