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Related Experiment Videos

Paregoric intoxication with pulmonary edema in infancy.

T B Rice

    Clinical Pediatrics
    |February 1, 1984
    PubMed
    Summary

    Paregoric intoxication can cause pulmonary edema in infants. Due to unclear medical benefits and serious risks, paregoric use in children should be discontinued.

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    Area of Science:

    • Pediatric Medicine
    • Toxicology
    • Pharmacology

    Background:

    • Paregoric, a camphorated tincture of opium, has been historically used for various pediatric ailments.
    • The precise mechanisms underlying opioid-induced pulmonary edema are not fully understood.
    • Concerns exist regarding the safety and efficacy of paregoric in infants.

    Observation:

    • A case study of a 3-week-old infant presenting with paregoric intoxication.
    • The infant developed significant pulmonary edema secondary to paregoric exposure.
    • Clinical presentation and management of the infant's respiratory distress.

    Findings:

    • Opioid use, including paregoric, is associated with potentially treatable pulmonary edema.
    • The exact pathophysiology of opioid-induced pulmonary edema remains elusive.
    • The clinical indication for using paregoric in pediatric patients is questionable.

    Implications:

    • The findings suggest that paregoric poses serious risks, such as pulmonary edema, in infants.
    • Abandoning the use of paregoric in pediatric patients is recommended due to severe complications.
    • Further research into the mechanisms of opioid-induced pulmonary edema is warranted.

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