Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Byssinosis. Inhalation challenge with polyphenol.

J H Edwards, T S AlZubaidy, R Altikriti

    Chest
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Haldane and the analysis of linkage.

    Journal of genetics·2017
    Same author

    THE SIGNIFICANCE OF PHLEBOLITHS.

    British medical journal·2010
    Same author

    Short bouts of mechanical loading are as effective as dexamethasone at inducing matrix production by human bone marrow mesenchymal stem cell.

    European cells & materials·2010
    Same author

    Aetiology and outcomes of adult superior oblique palsies: a modern series.

    Eye (London, England)·2008
    Same author

    Amendment effects on soil test phosphorus.

    Journal of environmental quality·2005
    Same author

    Sib-pairs in multifactorial disorders: the sib-similarity problem.

    Clinical genetics·2003
    Same journal

    The effect of a two-day stay at high altitude (2500 m) on right ventricular afterload and oxygen delivery in patients with pulmonary vascular disease A randomized controlled crossover trial.

    Chest·2026
    Same journal

    A Comparative Study of Radiation Exposure in Conventional and Robotic Bronchoscopy.

    Chest·2026
    Same journal

    Independent Prognostic Contributions of Anti-Ro52 and Anti-MDA5 in Autoimmune-Associated Interstitial Lung Disease.

    Chest·2026
    Same journal

    Lung aeration and gas exchange in SGA or AGA infants with moderate-severe BPD: secondary analysis of the PATH-BPD study.

    Chest·2026
    Same journal

    Lung Cancer Incidence and Mortality after Negative Low-Dose CT Screening Results.

    Chest·2026
    Same journal

    Symptom prevalence and impact on lung cancer risk in the SUMMIT study.

    Chest·2026
    See all related articles

    Researchers investigated the cause of byssinosis, a lung disease from cotton dust. Initial tests suggested a plant polyphenol caused symptoms, but later trials with affected workers showed no reaction, indicating a complex cause.

    Area of Science:

    • Occupational Medicine
    • Pulmonary Medicine
    • Environmental Health

    Background:

    • Byssinosis is a lung disease linked to cotton dust exposure.
    • Previous research often used in vitro tests with normal volunteers.
    • Identifying the specific etiologic agent in byssinosis remains challenging.

    Purpose of the Study:

    • To investigate the role of a specific cotton plant polyphenol in causing byssinosis symptoms.
    • To evaluate the direct effects of this polyphenol on byssinotic subjects.
    • To assess long-term pulmonary function changes in cotton dust-exposed workers.

    Main Methods:

    • Inhalation challenge tests with a condensed polyphenol isolated from cotton bracts.
    • Repeated challenge tests on 29 byssinotic subjects.

    Related Experiment Videos

  • Pulmonary function tests comparing polyphenol and saline challenges.
  • Comparison of pulmonary function between exposed workers and a control group.

    • Main Results:

    • Initial studies suggested a polyphenol triggered symptoms in byssinotic workers.
    • Subsequent challenge tests with the same polyphenol failed to reproduce symptoms in 29 subjects.
    • Pulmonary function tests showed no difference between polyphenol and saline challenges.
    • Long-term cotton dust exposure, especially with smoking, significantly impaired pulmonary function compared to controls.

    Conclusions:

    • The specific condensed polyphenol tested is unlikely to be the sole or primary cause of byssinosis symptoms.
    • Byssinosis likely results from a complex interaction of factors related to cotton dust exposure.
    • Long-term occupational exposure to cotton dust, exacerbated by smoking, has detrimental effects on lung function.