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Relationship between ascorbic acid and cell division.

R Liso, G Calabrese, M B Bitonti

    Experimental Cell Research
    |February 1, 1984
    PubMed
    Summary
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    Ascorbic acid is essential for cell division. Inhibiting its production with lycorine halts cell cycle progression, but this effect is reversible by adding more ascorbic acid.

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Molecular Biology

    Background:

    • Proliferating cells have high ascorbic acid demands for division.
    • Ascorbic acid deficiency can impede cell cycle progression.

    Purpose of the Study:

    • To investigate the role of ascorbic acid in cell division.
    • To determine the mechanism by which ascorbic acid regulates the cell cycle.

    Main Methods:

    • Utilized lycorine, an inhibitor of ascorbic acid biosynthesis, to induce deficiency.
    • Experimentally increased ascorbic acid concentrations to observe reversal effects.
    • Assessed cell cycle arrest at G1 and G2 phases using mitotic index (MI).

    Main Results:

    • Lycorine treatment significantly inhibited cell division, arresting the cell cycle primarily in the G1 phase.

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  • Increased ascorbic acid levels experimentally reversed lycorine's inhibitory effects on the mitotic index.
  • Isoascorbic acid, a structural analog, did not affect cell division, indicating ascorbic acid's specific action.

    • Conclusions:

    • Ascorbic acid plays a critical, specific role in regulating cell division.
    • Its function in the cell cycle may involve controlling the synthesis of hydroxyproline-containing proteins necessary for G1 and G2 phase progression.