Related Experiment Video

Updated: Aug 17, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Determining hepatic transport kinetics by mathematical modeling

B A Luxon, E L Forker

    Federation Proceedings
    |February 1, 1984
    PubMed

    More Related Videos

    An All-Human Hepatic Culture System for Drug Development Applications07:23

    An All-Human Hepatic Culture System for Drug Development Applications

    Published on: October 20, 2023

    A Comprehensive Rat Model For Assessing Hepatic Transport Pathways Through Simultaneous Lymphatic And Blood Vascular Sampling07:56

    A Comprehensive Rat Model For Assessing Hepatic Transport Pathways Through Simultaneous Lymphatic And Blood Vascular Sampling

    Published on: May 15, 2026

    Related Concept Videos

    Pharmacokinetic Models: Overview01:20

    Pharmacokinetic Models: Overview

    Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
    There are three primary types of models: empirical, compartment, and physiological. Empirical models, with minimal assumptions,...
    Model Approaches for Pharmacokinetic Data: Physiological Models01:15

    Model Approaches for Pharmacokinetic Data: Physiological Models

    Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
    Physiological Pharmacokinetic Models: Assumption with Protein Binding01:13

    Physiological Pharmacokinetic Models: Assumption with Protein Binding

    Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
    Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance01:07

    Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance

    Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
    A recent model describes pravastatin's hepatobiliary excretion, mediated...
    Pharmacokinetic Models: Comparison and Selection Criterion01:26

    Pharmacokinetic Models: Comparison and Selection Criterion

    Physiological and compartmental models are valuable tools used in studying biological systems. These models rely on differential equations to maintain mass balance within the system, ensuring an accurate representation of the dynamic processes at play.
    Physiological models take a detailed approach by considering specific molecular processes. They can predict drug distribution, metabolism, and elimination changes, providing a comprehensive understanding of how drugs interact with the body.
    Nonlinear Pharmacokinetics: Role of Transporters01:27

    Nonlinear Pharmacokinetics: Role of Transporters

    A drug's nonlinear kinetics can be influenced by a diverse range of transporter proteins that serve as crucial players in drug distribution. These transporters, found within cells, can enhance or reduce local drug concentrations by facilitating the influx or efflux of drugs. For instance, the expression of xenobiotic transporters can be influenced by factors such as age and gender, potentially impacting the linearity of drug response.
    Polymorphisms occurring in drug transporters can alter...