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Metastatic Crohn's disease
Journal of the American Academy of Dermatology
|January 1, 1984
Summary
Metastatic Crohn's disease, characterized by skin granulomas distant from the bowel, is rare. This report details two cases, including a unique facial erysipelas-like presentation, highlighting its association with colonic or rectal Crohn's disease.
Area of Science:
- Dermatology
- Gastroenterology
- Pathology
Background:
- Metastatic Crohn's disease (MCD) is a rare extraintestinal manifestation of Crohn's disease (CD).
- It involves granuloma formation in the skin, distant from the gastrointestinal tract.
- The pathogenesis of MCD remains incompletely understood.
Observation:
- This report describes two new cases of MCD.
- One patient presented with a facial erysipelas-like eruption, a previously undocumented presentation.
- Both patients had underlying gastrointestinal disease involving the colon or rectum.
Findings:
- A review of the literature identified nine previously reported cases of MCD.
- All documented cases of MCD, including the two presented here, were associated with gastrointestinal CD affecting the colon or rectum.
- Cutaneous manifestations of MCD can be diverse, including the erysipelas-like presentation.
Implications:
- These findings expand the known clinical spectrum of metastatic Crohn's disease.
- The consistent association with colonic or rectal CD suggests a potential link in disease localization.
- Further research is warranted to elucidate the mechanisms driving MCD and its varied presentations.