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Metastatic Crohn's disease.

M Lebwohl, R Fleischmajer, H Janowitz

    Journal of the American Academy of Dermatology
    |January 1, 1984
    PubMed
    Summary
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    Metastatic Crohn's disease, characterized by skin granulomas distant from the bowel, is rare. This report details two cases, including a unique facial erysipelas-like presentation, highlighting its association with colonic or rectal Crohn's disease.

    Area of Science:

    • Dermatology
    • Gastroenterology
    • Pathology

    Background:

    • Metastatic Crohn's disease (MCD) is a rare extraintestinal manifestation of Crohn's disease (CD).
    • It involves granuloma formation in the skin, distant from the gastrointestinal tract.
    • The pathogenesis of MCD remains incompletely understood.

    Observation:

    • This report describes two new cases of MCD.
    • One patient presented with a facial erysipelas-like eruption, a previously undocumented presentation.
    • Both patients had underlying gastrointestinal disease involving the colon or rectum.

    Findings:

    • A review of the literature identified nine previously reported cases of MCD.
    • All documented cases of MCD, including the two presented here, were associated with gastrointestinal CD affecting the colon or rectum.

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  • Cutaneous manifestations of MCD can be diverse, including the erysipelas-like presentation.

    • Implications:

    • These findings expand the known clinical spectrum of metastatic Crohn's disease.
    • The consistent association with colonic or rectal CD suggests a potential link in disease localization.
    • Further research is warranted to elucidate the mechanisms driving MCD and its varied presentations.