Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simple technique for measuring regional contractility by a modified strain guage arch.

S Kusachi, D Saito, O Nishiyama

    Japanese Circulation Journal
    |January 1, 1984
    PubMed
    Summary

    This study introduces a novel isometric myocardial force sensor using mechanical pins for atraumatic heart muscle attachment. The device accurately measures contractility changes without being affected by heart rate or blood pressure variations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Preoperative evaluation of pleural adhesions with dynamic chest radiography: a retrospective study of 146 patients with lung cancer.

    Clinical radiology·2022
    Same author

    Relationships among maxillofacial morphologies, bone properties, and bone metabolic markers in patients with jaw deformities.

    International journal of oral and maxillofacial surgery·2016
    Same author

    The frequency of Fabry disease with the E66Q variant in the α-galactosidase A gene in Japanese dialysis patients: a case report and a literature review.

    Clinical nephrology·2012
    Same author

    [One-stage coronary artery bypass grafting and revascularization in a patient with ischemic heart disease and arteriosclerosis obliterans].

    Kyobu geka. The Japanese journal of thoracic surgery·2011
    Same author

    Intermittent administration of a sustained-release prostacyclin analog ONO-1301 ameliorates renal alterations in a rat type 1 diabetes model.

    Prostaglandins, leukotrienes, and essential fatty acids·2010
    Same author

    Assessment of intraradicular bacterial composition by terminal restriction fragment length polymorphism analysis.

    Oral microbiology and immunology·2009

    Area of Science:

    • Cardiovascular Research
    • Biomedical Engineering
    • Myocardial Mechanics

    Background:

    • Accurate measurement of myocardial contractility is crucial for understanding cardiac function and disease.
    • Existing methods for measuring myocardial force can be invasive or technically challenging.

    Purpose of the Study:

    • To develop and validate a novel, easily implantable isometric myocardial force sensor.
    • To assess the sensor's sensitivity to contractility changes versus preload and afterload variations.

    Main Methods:

    • Modification of a commercial strain gauge arch with pins for mechanical myocardial coupling.
    • Controlled muscle stretch achieved using a machinist's vernier caliper during implantation.
    • In vivo testing in open-chest dogs to evaluate sensor performance.

    Related Experiment Videos

    Main Results:

    • The modified strain gauge arch functions as a stable and atraumatic isometric myocardial force sensor.
    • Sensor readings showed minimal sensitivity to changes in heart rate, left ventricular end-diastolic pressure, or aortic pressure.
    • The sensor accurately reflected the inotropic effects of pharmacological agents like isoproterenol and propranolol.

    Conclusions:

    • The modified strain gauge arch provides a reliable method for measuring myocardial contractility.
    • This sensor is insensitive to preload and afterload, making it a specific indicator of cardiac contractility.
    • The device offers a practical and less traumatic approach for myocardial force assessment in research settings.