Hemipelvectomy for liposarcoma: an unusual case and course

Area of Science:

• Oncology
• Surgical Oncology
• Medical Oncology

Background:

• Liposarcoma is a malignant mesenchymal tumor arising from adipose tissue.
• Pelvic and thigh liposarcomas can present significant surgical challenges due to location and size.
• Hemipelvectomy is a radical surgical procedure involving the removal of a portion of the pelvis.

Observation:

• A patient presented with a large liposarcoma involving the upper thigh and pelvis.
• The tumor was initially considered inoperable due to its extensive nature.
• The patient received neoadjuvant therapy consisting of radiotherapy and chemotherapy.

Findings:

• Preoperative radiotherapy and chemotherapy resulted in significant tumor regression and induced tumor necrosis.
• The neoadjuvant treatment facilitated the conversion of the previously inoperable tumor into an operable one.
• Successful surgical resection via hemipelvectomy was achieved following neoadjuvant therapy.

Implications:

• Neoadjuvant chemoradiotherapy can be a viable strategy for managing locally advanced or inoperable liposarcomas.
• This approach may improve surgical resectability and patient outcomes in complex cases.
• Further research into optimal neoadjuvant protocols for liposarcoma is warranted.