Effect of naltrexone on food intake and hoarding in white-footed mice (Peromyscus)

Increases in food consumption and hoarding in mammals have been shown to be immediate and preparative adjustments to the energetic stresses of temperate winters. The sensitivity of these behaviors to the opiate antagonist naltrexone was tested in non-deprived white-footed mice (Peromyscus leucopus). Mice received naltrexone hydrochloride intraperitoneally (10 mg/kg in saline vehicle) once daily for four consecutive days subsequent to an equivalent period of injection with saline as control. Daily food intake was significantly (p less than 0.05) lower after naltrexone treatment. Hoarding, as assessed by logarithmic hoarding scores and the weight of cached food, was not affected by administration of this drug at this dosage. These results suggest that hoarding, a complex behavioral pattern that does not immediately affect internal energy stores, may not fall within the opiate regulatory scheme.