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Updated: Jul 18, 2026

Gastrointestinal Motility Monitor (GIMM)
Published on: December 1, 2010
Abstract:
Metoclopramide, a procainamide derivative that markedly stimulates peristalsis in a variety of gastrointestinal tissues, demonstrated a significant dose-dependent effect on rat, canine, and human ureters studied in vitro. A moderate increase in phasic activity was seen at low concentrations with striking inhibition noted at higher concentrations. In the dog, atropine 0.6 microgram/ml inhibited the former while procaine 400 micrograms/ml stimulated the latter. Surgically produced, chronically dilated canine ureters were also stimulated by metoclopramide. Metoclopramide may be useful in states of disordered ureteral motility.
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