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Prenatal intramedullary gliofibroma. A light and electron microscope study.

J R Iglesias, E P Richardson, F Collia

Acta Neuropathologica

|January 1, 1984

Summary

This report details a rare congenital spinal cord tumor, a gliofibroma, found in an infant. The tumor, composed of astrocytes and fibroblasts, showed no signs of malignancy.

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Area of Science:

Neurology
Oncology
Pediatric Pathology

Background:

Congenital intramedullary spinal cord tumors are rare pediatric conditions.
Early diagnosis and characterization are crucial for understanding disease progression and treatment.

Observation:

An 11-day-old paraplegic infant presented with hypotonia and muscle atrophy.
Myelography revealed a complete block between T-5 and T-8, indicating spinal cord compression.
Surgical exploration identified an elongated intramedullary tumor mass seamlessly integrated with neural tissue.

Findings:

Histopathological analysis revealed a tumor composed of intermingled, well-differentiated astrocytes and fibroblasts.
Electron microscopy showed these cells were often enveloped by a shared basal lamina, with absent intercellular junctions.

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Abundant gliofibrils and interstitial collagen/reticulin fibers were noted, with no histological evidence of malignancy.

The tumor was classified as a gliofibroma, likely arising prenatally.

Implications:

This case expands the understanding of rare congenital spinal cord tumors.
The findings contribute to the histopathological classification of glial and mesenchymal-derived tumors.
Further research into the embryogenesis and behavior of such congenital tumors is warranted.