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Related Experiment Videos

Accelerated junctional rhythms during oral verapamil therapy.

J B Schwartz, M Jeang, A E Raizner

    American Heart Journal
    |March 1, 1984
    PubMed
    Summary

    Oral verapamil increased junctional pacemaker activity in patients with supraventricular tachyarrhythmias, leading to atrioventricular (AV) dissociation and accelerated junctional rhythms. This effect was not observed in patients with chest pain syndromes.

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    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Supraventricular tachyarrhythmias, particularly AV nodal reentry, can involve junctional rhythms.
    • Verapamil is a calcium channel blocker used in managing various cardiac conditions.

    Purpose of the Study:

    • To investigate the effects of oral verapamil on atrioventricular (AV) dissociation and accelerated junctional rhythms.
    • To determine if verapamil influences junctional pacemaker activity in different patient groups.

    Main Methods:

    • Observational study involving 59 patients receiving oral verapamil.
    • Analysis of electrocardiographic data to assess AV dissociation and junctional rhythm frequency.

    Main Results:

    • Accelerated junctional rhythms and AV dissociation were frequently observed in patients with supraventricular tachyarrhythmias.

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  • Verapamil administration resulted in an asymptomatic increase in junctional pacemaker activity in these patients.
  • Verapamil did not increase junctional rhythm frequency or suppress their escape role in patients with chest pain syndromes.

    • Conclusions:

    • Oral verapamil can increase the activity of junctional pacemakers in patients with supraventricular tachyarrhythmias.
    • The electrophysiological effects of verapamil on junctional rhythms differ between patients with tachyarrhythmias and those with chest pain syndromes.