Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Errors in predicting functional capacity for postmyocardial infarction patients using a modified Bruce protocol.

M Sullivan, M D McKirnan

    American Heart Journal
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of ultrasonography, radiography and a single computed tomography slice for fluid identification within the feline tympanic bulla.

    Veterinary journal (London, England : 1997)·2006
    Same author

    Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks HT.

    Journal of pharmacological and toxicological methods·2006
    Same author

    Use of reconstructed computed tomography for the assessment of joint spaces in the canine elbow.

    The Journal of small animal practice·2006
    Same author

    Ethical considerations in managed care: a commentary.

    UMKC law review·2005
    Same author

    Thoracic high-resolution computed tomographic findings in dogs with canine idiopathic pulmonary fibrosis.

    The Journal of small animal practice·2005
    Same author

    Histomorphometric characterisation of shared and non-shared cotyledonary villus territories of monochorionic placentae in relation to pregnancy complications.

    Placenta·2005
    Same journal

    International study of Coronary Microvascular Angina (iCorMicA): a registry-based diagnostic study and nested randomized trial.

    American heart journal·2026
    Same journal

    Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial.

    American heart journal·2026
    Same journal

    Revised Lipid-Lowering Therapy Guidelines in a Nationally Representative Sample.

    American heart journal·2026
    Same journal

    Cardiometabolic Health of Low- and Higher-Income Adults in the United States, 2009-2023.

    American heart journal·2026
    Same journal

    Moving Beyond Technical Capability to Regulatory Integration for Digital Health Technology Devices-Brief Communication from the Cardiovascular Sciences Research Consortium.

    American heart journal·2026
    Same journal

    THE SOCIETY OF CRITICAL CARE CARDIOLOGY - RATIONALE, BLUEPRINT, AND LESSONS LEARNED IN THE CREATION OF A NEW MULTIDISCIPLINARY PROFESSIONAL ORGANIZATION.

    American heart journal·2026
    See all related articles

    Post-myocardial infarction (MI) patients show reduced oxygen uptake during exercise. This study found lower VO2 and increased anaerobic metabolism in post-MI patients compared to healthy individuals, impacting functional capacity predictions.

    Area of Science:

    • Cardiology
    • Exercise Physiology
    • Metabolic Studies

    Background:

    • The modified Bruce protocol is standard for assessing functional capacity in post-myocardial infarction (MI) patients.
    • Concerns exist regarding the accuracy of standard workload oxygen uptake predictions for post-MI individuals.
    • Myocardial damage may alter physiological responses to exercise.

    Purpose of the Study:

    • To compare oxygen uptake (VO2) and lactic acid levels during a modified Bruce protocol in post-MI patients versus healthy subjects.
    • To investigate the impact of myocardial damage on exercise oxygen kinetics and anaerobic metabolism.
    • To evaluate the predictive accuracy of the modified Bruce protocol for functional capacity in post-MI patients.

    Main Methods:

    • Recruited 12 post-MI patients and 12 healthy male subjects.

    Related Experiment Videos

  • Administered a modified Bruce treadmill protocol.
  • Measured oxygen uptake (VO2) and venous blood lactic acid concentration at various stages.

    • Main Results:

    • Post-MI patients exhibited significantly lower mean oxygen uptake (VO2) during the initial stages (p < 0.001).
    • Lactic acid differences were noted only at stage 4, but a higher respiratory exchange ratio in post-MI patients suggested increased anaerobic metabolism and lactic acid buffering (p < 0.001 at stage 3).
    • Measured VO2 was substantially lower than predicted values for post-MI patients, both from cardiac patient norms and healthy subject data.

    Conclusions:

    • Myocardial damage appears to slow oxygen uptake kinetics, leading to a greater oxygen deficit at standard exercise workloads.
    • Increased anaerobic metabolism, indicated by the respiratory exchange ratio, may compensate for the exercise-induced oxygen deficit in post-MI patients.
    • Current exercise protocols may overestimate functional capacity in post-MI patients due to altered oxygen uptake kinetics.