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Extracardiac adverse effects of flecainide
The American Journal of Cardiology
|February 27, 1984
Summary
Flecainide is generally well-tolerated therapeutically. Most adverse events like dizziness and visual disturbances were mild and decreased over time, with few patients discontinuing treatment.
Area of Science:
- Pharmacology
- Clinical Trials
- Cardiology
Background:
- Flecainide is an antiarrhythmic medication.
- Assessing long-term safety and efficacy is crucial for patient management.
Purpose of the Study:
- To evaluate the safety and efficacy of therapeutic doses of flecainide.
- To identify and quantify adverse experiences associated with flecainide treatment.
Main Methods:
- Multicenter short-term safety and efficacy study.
- Supported by data from several long-term patient studies.
- Adverse experiences were systematically recorded and analyzed.
Main Results:
- Therapeutic flecainide doses were well tolerated by most patients.
- Most frequent extracardiac adverse experiences: dizziness (30%) and visual disturbances (28%).
- Adverse experiences decreased over time and were often intermittent.
Conclusions:
- Flecainide demonstrates good tolerability in most patients.
- Early identification of intolerance is likely.
- No chronic toxic effects were observed in long-term studies.