Dietary cholesterol and lung cancer risk among Japanese men in Hawaii

Dietary cholesterol intake was estimated for 7539 men clinically examined from 1965 to 1968, as part of a prospective cohort study. After 15 yr of surveillance, 113 incidence cases of lung cancer have been identified. We found no significant association between dietary cholesterol intake and lung cancer risk, either before or after adjustment for age and pack-years of cigarette smoking. Cases under age 60 at examination did consume more dietary cholesterol than controls of the same age group, but no significant age/dietary cholesterol interaction effect could be found. No significant association could be found with any of the subgroups of cases defined by: clinical stage of disease, histological type, or time interval from examination to diagnosis.