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Related Experiment Videos

Procainamide-induced thrombocytopenia.

R Rosenstein, R E Kosfeld, L Leight

    American Journal of Hematology
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Procainamide can cause severe thrombocytopenia (low platelet count), likely immune-mediated. Prednisone treatment rapidly improves platelet counts in affected patients.

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    Area of Science:

    • Hematology
    • Clinical Pharmacology

    Background:

    • Procainamide is an antiarrhythmic drug.
    • Drug-induced thrombocytopenia is a potential adverse effect.

    Observation:

    • An 81-year-old female presented with severe thrombocytopenia after 2 months of procainamide use.
    • Bone marrow examination revealed numerous megakaryocytes without anemia or leukopenia.

    Findings:

    • Platelet counts normalized with prednisone treatment and recurred upon steroid withdrawal.
    • Discontinuation of procainamide resolved thrombocytopenia; readministration caused recurrence.

    Implications:

    • Procainamide can induce isolated, immune-mediated thrombocytopenia.
    • Prednisone offers prompt therapeutic benefit for procainamide-induced thrombocytopenia.