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Phencyclidine use during pregnancy.

N L Golden, B R Kuhnert, R J Sokol

    American Journal of Obstetrics and Gynecology
    |February 1, 1984
    PubMed
    Summary
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    This study investigated phencyclidine (PCP) use in pregnant women. Researchers found that 0.8% of pregnant women used PCP, with users often being younger, white, and having a history of polydrug abuse.

    Area of Science:

    • Obstetrics and Gynecology
    • Perinatal Medicine
    • Pharmacology

    Background:

    • Phencyclidine (PCP) is a frequently abused substance.
    • PCP is known to cross the placenta, posing risks to fetal development.

    Purpose of the Study:

    • To prospectively determine the prevalence of phencyclidine (PCP) use among pregnant women.
    • To characterize the demographic and substance abuse profiles of pregnant PCP users.

    Main Methods:

    • Screening of 2,327 pregnant women using questionnaires and enzyme-mediated immunoassay technique (EMIT) urine testing.
    • Comparison of phencyclidine users with a control group of nonusers.

    Main Results:

    • Nineteen women (0.8%) were identified as current phencyclidine (PCP) users during pregnancy; 149 (6.4%) were past users.

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  • Phencyclidine users were more likely to be white, younger, and of lower parity compared to nonusers.
  • A majority of phencyclidine users reported a history of multiple drug abuse.

    • Conclusions:

    • Phencyclidine (PCP) use during pregnancy is a significant concern, despite reported prevalence potentially underestimating the issue.
    • Pregnant women using PCP often exhibit a pattern of polysubstance abuse and specific demographic characteristics.
    • Further research and interventions are needed to address perinatal PCP exposure risks.