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Age- and sex-related differences in urinary cortisol level
Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 14, 1984
Summary
The 24-hour urinary cortisol level is age-dependent in adults. While creatinine correction impacts sex differences, age remains a key factor in cortisol levels, with no significant circadian rhythm variations found.
Area of Science:
- Endocrinology
- Clinical Chemistry
Background:
- Cortisol, a key stress hormone, exhibits diurnal variations.
- Understanding age and sex influences on 24-hour urinary cortisol is crucial for accurate clinical interpretation.
Purpose of the Study:
- To investigate the influence of age and sex on 24-hour urinary cortisol levels.
- To assess the impact of creatinine correction on these age- and sex-related variations.
Main Methods:
- Comparative analysis of 24-hour urinary cortisol levels in normal adult groups.
- Age- and sex-matched group comparisons.
- Cortisol levels corrected for urinary creatinine excretion.
Main Results:
- 24-hour urinary cortisol levels demonstrated age-dependency in both sexes.
- Significant sex differences were observed in younger age groups (up to 20-24 years).
- Creatinine correction partially reduced age-related variations and altered sex differences across age groups.
Conclusions:
- Age is a significant determinant of 24-hour urinary cortisol excretion.
- Creatinine correction modifies, but does not eliminate, age and sex-related differences in urinary cortisol.
- No significant age or sex differences were found in the circadian rhythm of cortisol excretion.