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Gallium scintigraphy in bone infarction. Correlation with bone imaging.

R R Armas, S J Goldsmith

    Clinical Nuclear Medicine
    |January 1, 1984
    PubMed
    Summary
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    Gallium-67 imaging shows decreased uptake in acute bone infarction for sickle cell disease patients, but normal uptake in healing infarcts. This helps differentiate active bone damage from recovery stages.

    Area of Science:

    • Nuclear medicine
    • Hematology
    • Radiology

    Background:

    • Sickle cell disease commonly causes bone complications, including avascular necrosis and bone infarction.
    • Gallium-67 scintigraphy is a nuclear medicine technique used to detect inflammation and infection.
    • Bone scans (technetium-99m) are standard for evaluating bone abnormalities.

    Purpose of the Study:

    • To evaluate the utility of gallium-67 citrate imaging in diagnosing bone infarction in sickle cell disease.
    • To correlate gallium-67 findings with bone scan results in these patients.

    Main Methods:

    • Nine patients with sickle cell disease and suspected bone infarction were included.
    • Gallium-67 scintigraphy was performed and findings were compared with bone scan imaging.

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  • Image interpretation focused on gallium uptake patterns in areas of infarction.

    • Main Results:

    • Acute bone infarcts in sickle cell disease patients demonstrated decreased or absent gallium-67 uptake.
    • Bone scans in acute infarction showed variable uptake.
    • Healing bone infarcts exhibited normal gallium-67 uptake, correlating with increased bone scan activity.

    Conclusions:

    • Gallium-67 scintigraphy can help differentiate acute bone infarction from healing infarcts in sickle cell disease.
    • The pattern of gallium uptake provides valuable information for assessing bone infarct activity in this patient population.