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Esophagitis associated with Candida infection in a neonate

A Petru, P H Azimi

    Clinical Pediatrics
    |March 1, 1984
    PubMed

    Insights

    A 14-day-old infant with Candida stomatitis developed esophagitis. Oral Mycostatin suspension effectively treated the infant, resolving both stomatitis and emesis, demonstrating the efficacy of nonabsorbable antifungals.

    Area of Science:

    • Pediatrics
    • Mycology
    • Gastroenterology

    Background:

    • Infant oral candidiasis (thrush) is common.
    • Esophageal candidiasis is a potential complication, though its incidence in healthy infants is not well-established.
    • Gastrointestinal candidiasis can present with varied symptoms.

    Observation:

    • A 14-day-old infant presented with Candida stomatitis and frequent emesis.
    • Barium esophagram revealed esophagitis.
    • The infant received oral Mycostatin (nystatin) suspension.

    Findings:

    • The infant showed a prompt clinical response, with resolution of emesis and stomatitis.
    • Repeat esophagram confirmed complete resolution of esophageal mucosal abnormalities after seven days of therapy.
    • The nonabsorbable antifungal agent was effective in treating the infant's Candida esophagitis.

    Implications:

    • This case highlights the successful treatment of Candida esophagitis in an infant using oral nystatin.
    • It suggests that oral nonabsorbable antifungal agents can be effective for this complication.
    • Further studies are warranted to determine the incidence and optimal therapeutic strategies for Candida esophagitis in otherwise healthy infants.

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