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Related Experiment Videos

Low-dose methotrexate kinetics in arthritis.

J Edelman, D F Biggs, F Jamali

    Clinical Pharmacology and Therapeutics
    |March 1, 1984
    PubMed
    Summary

    Low-dose methotrexate (MTX) administered intramuscularly or intravenously showed similar absorption and elimination in patients with rheumatoid or psoriantc arthritis. Serum MTX levels remained therapeutic for 24 hours without accumulation.

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    SPINAL ANAESTHESIA IN ACUTE OBSTRUCTION.

    British medical journal·2010

    Area of Science:

    • Pharmacokinetics
    • Rheumatology
    • Immunology

    Background:

    • Rheumatoid arthritis and psoriatic arthritis are chronic inflammatory conditions.
    • Methotrexate (MTX) is a common disease-modifying antirheumatic drug (DMARD).
    • Understanding MTX pharmacokinetics is crucial for optimizing treatment in inflammatory arthritis.

    Purpose of the Study:

    • To compare the pharmacokinetic profiles of low-dose methotrexate administered via intramuscular (IM) versus intravenous (IV) routes in patients with inflammatory arthritis.
    • To assess serum MTX concentrations over 24 hours and evaluate drug accumulation.

    Main Methods:

    • Twelve patients with rheumatoid or psoriatic arthritis received a 10-mg bolus dose of MTX (n=6 IM, n=6 IV).
    • Serum MTX concentrations were measured using radioimmunoassay over a 24-hour period.
    • Pharmacokinetic parameters including half-life (t 1/2), volume of distribution, and clearance were analyzed.

    Main Results:

    • Intramuscular administration resulted in rapid and complete absorption of methotrexate.
    • No significant differences were observed in mean drug half-life, volume of distribution, or total body clearance between the IM and IV groups.
    • Serum MTX concentrations in most patients remained above the critical level of 0.01 mumol for 24 hours without evidence of drug accumulation.

    Conclusions:

    • Low-dose methotrexate exhibits comparable pharmacokinetic behavior when administered via IM or IV routes in patients with inflammatory arthritis.
    • The observed pharmacokinetic profile of low-dose MTX in arthritis patients mirrors that seen with higher doses used in oncology.
    • These findings support the efficacy and predictable disposition of low-dose MTX for managing rheumatoid and psoriatic arthritis.

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