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Related Experiment Video

Updated: Feb 6, 2026

Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
04:13

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Published on: September 27, 2024

882

Mandibular osteomas in familial polyposis coli.

S Bülow, J O Søndergaard, I Witt

    Diseases of the Colon and Rectum
    |February 1, 1984
    PubMed
    Summary

    Mandibular osteomas are frequently found in familial polyposis coli patients, even without Gardner's syndrome signs. Orthopantomography aids in early diagnosis for relatives of polyposis patients.

    Area of Science:

    • Oncology
    • Genetics
    • Radiology

    Background:

    • Familial polyposis coli (FPC) is an inherited condition predisposing to colorectal cancer.
    • Gardner's syndrome is a subtype characterized by FPC and extracolonic manifestations, including osteomas.
    • The distinction between FPC and Gardner's syndrome based on clinical extracolonic signs is debated.

    Purpose of the Study:

    • To investigate the prevalence of mandibular osteomas in patients with familial polyposis coli.
    • To assess the diagnostic utility of orthopantomography in identifying FPC-associated abnormalities.
    • To re-evaluate the clinical entity of Gardner's syndrome.

    Main Methods:

    • Orthopantomograms (mandibular X-rays) were obtained for 46 FPC patients without clinical Gardner's syndrome signs.

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  • A control group of 46 age- and sex-matched individuals was included.
  • Statistical analysis compared osteoma prevalence between groups.

    • Main Results:

    • A significantly higher prevalence of mandibular osteomas was observed in FPC patients (76.1%) compared to controls (4.3%).
    • Osteomas were frequent even in FPC patients lacking other clinical signs of Gardner's syndrome.
    • The difference in osteoma occurrence was statistically significant (P < 0.0005).

    Conclusions:

    • Orthopantomography of the mandible is a valuable supplementary diagnostic tool for first-degree relatives of FPC patients.
    • The high incidence of mandibular osteomas in FPC patients suggests it may be an intrinsic feature, not exclusive to Gardner's syndrome.
    • The findings support the reclassification of Gardner's syndrome, questioning its status as a distinct clinical entity.