Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tobramycin-furosemide interaction.

J S Kaka, C Lyman, D J Kilarski

    Drug Intelligence & Clinical Pharmacy
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Furosemide can increase tobramycin levels in patients with edema, raising risks for kidney and ear toxicity. Careful monitoring is crucial when using these drugs together.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression.

    American journal of respiratory and critical care medicine·1995
    Same author

    Malassezia and Trichosporon: two emerging pathogenic basidiomycetous yeast-like fungi.

    Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology·1994
    Same author

    Bioavailability of ibuprofen from oral and suppository preparations in rats.

    Research communications in chemical pathology and pharmacology·1992
    Same author

    Antifungal effects of the nonlinear pharmacokinetics of cilofungin, a 1,3-beta-glucan synthetase inhibitor, during continuous and intermittent intravenous infusions in treatment of experimental disseminated candidiasis.

    Antimicrobial agents and chemotherapy·1991
    Same author

    Concurrent bromosulphophthalein and antipyrine administration to assess liver blood flow and hepatic enzymes in rats.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·1991
    Same author

    Evaluation of hepatic dysfunction in endotoxin pretreated rats using tolbutamide as a marker.

    European journal of drug metabolism and pharmacokinetics·1990
    Same journal

    Profile of prescription medication in a pediatric population.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    SI units in drug therapeutics.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Physicians' review of significant interventions by clinical pharmacists in inpatient care.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Possible interaction of ranitidine with phenytoin.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Famotidine-associated mental confusion in elderly patients.

    Drug intelligence & clinical pharmacy·1988
    Same journal

    Intravenous self-administration of elemental mercury: efficacy of dimercaprol therapy.

    Drug intelligence & clinical pharmacy·1988
    See all related articles

    Area of Science:

    • Pharmacology
    • Nephrology
    • Critical Care Medicine

    Background:

    • A 70-year-old female with congestive heart failure presented with worsening edema and shortness of breath.
    • Gram-negative bacilli were identified, prompting treatment with tobramycin.

    Observation:

    • Tobramycin dosing was adjusted using the Sawchuk-Zaske method.
    • Furosemide was administered, leading to significant changes in tobramycin pharmacokinetics.

    Findings:

    • Following furosemide administration, tobramycin peak and trough levels increased substantially.
    • The volume of distribution for tobramycin decreased by 40% after furosemide was given.

    Implications:

    • Moderate doses of furosemide in edematous patients receiving tobramycin can elevate drug levels.

    Related Experiment Videos

  • This elevation increases the risk of tobramycin-induced ototoxicity and nephrotoxicity.
  • Clinical vigilance and therapeutic drug monitoring are essential in such cases.