Hormonal profile of benign breast disease and premenstrual mastodynia

The Authors report their own results concerning plasma hormonal dosages in Benign Breast Disease (BBD) and Premenstrual Mastodynia (PM). Dosages were realized during the second phase of the cycle, 4 to 8 days following ovulation, according to the basal body temperature. 171 Patients were studied: fibro-cystic disease 82 cases; BBD + severe PM 71 cases; and isolated PM 18 cases. It was shown that the levels of Estradiol and Progesterone were within normal ranges in a great majority of cases; it was the same for the PG/E2 Ratio. The Prolactin levels were within the physiological norms; the responses to TRH were normal, and elevated only in a few cases. Based only on hormonal dosages, we concluded that there was no estrogeno-luteal imbalance nor dysprolactinemia in BBD and/or PM.