Immunodiagnosis in gynaecologic oncology: possibilities and limitations

The theory of Immunological Surveillance suggested by Burnet has been the object of many criticisms over the last years, but the study and the clinical applications of tumours immunology still show a remarkable interest with attracting prospects for the future. Some markers for human tumours cells, detected by RIA assay (TA4 for cervical cancer, CEA for ovarian cancer and alpha-FP for Endodermal Sinus Tumour) allow accuracy in neoplastic patients. The study of the tumoural patient's immunologic status could point out diagnostic and prognostic criteria and is likely to be used in the future for screening groups at risk for developing neoplasia.