Rabbit immunization to xenogeneic red blood cells following anterior eye chamber inoculation

Inoculation of human red blood cells (HRBC) into the anterior chamber of the eye (AC) of rabbits effectively stimulated systemic antibody production. Intraocular (i.o.) inoculation was observed to be more effective a route of immunization than i.v. or i.m. inoculation of antigen. These results contradict the accepted belief that the AC is an immunologically privileged site in the body.