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Related Experiment Videos

Serum theophylline during acute asthmatic attacks.

J Tønnesen

    International Archives of Allergy and Applied Immunology
    |January 1, 1984
    PubMed
    Summary

    Many patients with asthma or chronic bronchitis experience subtherapeutic serum theophylline levels during acute attacks, indicating undertreatment. Some patients are also overmedicated, highlighting the need for careful monitoring of theophylline derivatives.

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    Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology·1984

    Area of Science:

    • Pulmonary Medicine
    • Clinical Pharmacology

    Background:

    • Theophylline is a common medication for asthma and chronic bronchitis.
    • Acute exacerbations require careful management of bronchodilator therapy.

    Purpose of the Study:

    • To assess serum theophylline levels in patients experiencing acute asthma attacks.
    • To identify the prevalence of subtherapeutic and supratherapeutic theophylline levels.

    Main Methods:

    • Venous blood samples were collected from 41 patients with acute asthma or chronic bronchitis.
    • Serum theophylline concentrations were analyzed using liquid column chromatography.
    • Patients were on one of five different theophylline preparations.

    Main Results:

    • 26 out of 41 patients (63%) had subtherapeutic theophylline levels.
    • 5 patients (12%) had levels above the therapeutic range.
    • 10 patients (24%) had therapeutic theophylline levels.

    Conclusions:

    • A significant proportion of patients with acute asthma or chronic bronchitis are undertreated with theophylline.
    • Overmedication with theophylline also occurs, necessitating therapeutic drug monitoring.
    • Optimizing theophylline dosage is crucial for managing acute respiratory conditions.

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