Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Electrocardiogram and high plasma digoxin concentration.

Z Duraković, B Vrhovac, F Plavsić

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Access to information on drug regulation in the countries of Central and Eastern Europe.

    The International journal of risk & safety in medicine·2013
    Same author

    Prevalence of metabolic syndrome and related metabolic traits in an island population of the Adriatic.

    Annals of human biology·2011
    Same author

    Sudden cardiac death due to physical exercise in male competitive athletes. A report of six cases.

    The Journal of sports medicine and physical fitness·2006
    Same author

    Sudden death due to recreational exercise in physicians.

    Collegium antropologicum·2003
    Same author

    Angiotensin-converting enzyme gene polymorphism, lipids, and apolipoproteins in menopausal women on hormone replacement therapy.

    Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2002
    Same author

    Sudden death due to physical exercise in the elderly.

    Collegium antropologicum·2002

    Elevated plasma digoxin levels correlate with clinical symptoms and ECG changes. S-T segment depression is a more reliable indicator of digitalis effect than Q-T interval or P-T-Q index.

    Area of Science:

    • Cardiology
    • Clinical Pharmacology

    Background:

    • Digoxin is a cardiac glycoside used to treat heart failure and arrhythmias.
    • Monitoring plasma digoxin concentrations is crucial for therapeutic efficacy and toxicity.
    • Electrocardiogram (ECG) findings can indicate digoxin toxicity.

    Purpose of the Study:

    • To investigate the correlation between plasma digoxin concentrations and ECG findings.
    • To identify reliable ECG indicators of digoxin effect and toxicity.

    Main Methods:

    • Analysis of plasma digoxin concentrations in 48 patients.
    • Evaluation of ECG parameters including rhythm, conduction, corrected Q-T interval, P-T-Q index, and P-R interval.
    • Correlation of ECG findings with clinical symptoms of digoxin overdose.

    Related Experiment Videos

    Main Results:

    • Significantly elevated plasma digoxin concentrations (≥2.5 µg/l) correlated with clinical symptoms and ECG abnormalities in 48 patients.
    • Rhythm and conduction disturbances were observed in 23 patients.
    • No significant correlation was found between plasma digoxin concentrations and corrected Q-T interval (r=0.19), P-T-Q index (r=0.27), or prolonged P-Q interval (r=0.32).
    • S-T segment depression, particularly of the decreasing type, was prevalent and suggested as a more reliable indicator of digitalis effect.

    Conclusions:

    • Elevated plasma digoxin concentrations are associated with clinical and electrocardiographic signs of toxicity.
    • S-T segment depression appears to be a more sensitive ECG marker for digitalis effect compared to corrected Q-T interval, P-T-Q index, or prolonged P-R interval.