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Related Experiment Videos

Bioavailability of naproxen sodium suppositories.

O N Gamst, A K Vesje, J Aarbakke

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |February 1, 1984
    PubMed
    Summary

    Naproxen sodium suppositories offer faster absorption and therapeutic naproxen concentrations within one hour. This study found them safe and reliable compared to naproxen tablets and suppositories.

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    Area of Science:

    • Pharmacology
    • Drug Delivery Systems

    Background:

    • Naproxen sodium exhibits superior bioavailability and absorption compared to naproxen in tablet forms.
    • Suppository formulations offer an alternative route for naproxen administration.

    Purpose of the Study:

    • To compare the pharmacokinetic profiles of naproxen sodium suppositories with naproxen tablets and naproxen suppositories.
    • To evaluate the bioavailability, plasma concentrations, and safety of naproxen sodium suppositories.

    Main Methods:

    • Two randomized crossover studies were conducted in healthy volunteers.
    • Study 1 compared naproxen sodium suppositories (500 mg naproxen equivalent) with naproxen tablets (500 mg).
    • Study 2 compared naproxen sodium suppositories with naproxen suppositories.

    Main Results:

    • Naproxen sodium suppositories demonstrated a significantly shorter Tmax (1.4 h) compared to naproxen tablets (2.4 h).
    • No significant differences in bioavailability or biologic half-life were observed between formulations.
    • Naproxen sodium suppositories achieved therapeutic naproxen concentrations within the first hour post-administration.

    Conclusions:

    • Naproxen sodium suppositories are a safe, reliable, and effective method for naproxen administration.
    • This formulation provides rapid absorption and therapeutic drug levels.
    • Further research may explore patient tolerance and efficacy in specific populations.

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