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Hemodynamic effects of cutaneously administered isosorbide dinitrate ointment
International Journal of Clinical Pharmacology and Biopharmacy
|July 1, 1978
Summary
Topical isosorbide dinitrate ointment effectively reduced hemodynamic parameters like heart rate and blood pressure in healthy volunteers. This vasodilator decreased myocardial oxygen demand for over six hours.
Area of Science:
- Cardiology
- Pharmacology
- Physiology
Background:
- Nitrate vasodilators are crucial in managing cardiovascular conditions.
- Transdermal drug delivery offers an alternative route for therapeutic agents.
Purpose of the Study:
- To evaluate the hemodynamic effects of a 10% isosorbide dinitrate ointment.
- To assess the duration of action and impact on myocardial oxygen consumption.
Main Methods:
- Nine healthy volunteers received approximately 40 mg of 10% isosorbide dinitrate ointment.
- Hemodynamic parameters were monitored noninvasively using echocardiography for six hours.
Main Results:
- Significant reductions in heart rate, cardiac output, systolic blood pressure, and intracardiac diameters were observed within 30 minutes.
- Systolic blood pressure normalized by the end of the six-hour period.
- Myocardial oxygen consumption was reduced for over six hours due to decreased left ventricular workload.
Conclusions:
- Topical isosorbide dinitrate ointment demonstrates significant and sustained hemodynamic effects.
- This formulation effectively reduces myocardial oxygen demand, suggesting potential therapeutic applications.