Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Bioavailability of digoxin in capsules.

L Padeletti, A Brat

International Journal of Clinical Pharmacology and Biopharmacy

|July 1, 1978

Summary

This study found that a commercial digoxin capsule has inadequate bioavailability, differing from previous research. Bioavailability was similar between capsules and tablets in single-dose and steady-state trials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Past, Present, and Future of Dynamic Kidney and Liver Preservation and Resuscitation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016

Same author

Implantable cardioverter defibrillator in sport participation.

International journal of sports medicine·2014

Same author

Atrial fibrillation in athletes.

International journal of sports medicine·2012

Same author

Which factors predict the behavior of ventricular extrasystoles in athletes over time?

Scandinavian journal of medicine & science in sports·2012

Same author

Incidence of paroxysmal atrial tachycardias in patients treated with cardiac resynchronization therapy and continuously monitored by device diagnostics.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology·2009

Same author

The evolution of cardiac electrophysiology in the XIX century: historical highlights.

Minerva cardioangiologica·2008

Area of Science:

Pharmacology
Drug Delivery Systems

Background:

Digoxin is a critical medication for heart failure and arrhythmias.
Assessing the bioavailability of different digoxin formulations is essential for therapeutic efficacy.
Previous studies on digoxin bioavailability used experimental preparations, necessitating research on commercial products.

Purpose of the Study:

To evaluate the bioavailability of a commercially available digoxin solution in capsule form.
To compare the bioavailability of digoxin capsules with standard digoxin tablets.
To identify potential issues with the bioavailability of the commercial digoxin capsule.

Main Methods:

Single-dose pharmacokinetic study.
Steady-state pharmacokinetic study.
Comparison of bioavailability data between capsules and tablets.

Main Results:

The bioavailability of the commercial digoxin capsule was found to be inadequate.
Data obtained differed significantly from previously reported findings using experimental preparations.
Bioavailability was comparable between the digoxin capsules and standard digoxin tablets in both single-dose and steady-state studies.

Conclusions:

The commercial digoxin capsule formulation presents a problem of inadequate bioavailability.
Clinical implications of this finding require further investigation.
This study highlights the importance of evaluating commercial drug formulations independently.

Related Experiment Videos