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Exocrine pancreatic function in diabetes mellitus
Journal of Clinical Pathology
|March 1, 1984
Summary
Diabetes patients show reduced pancreatic function, especially those with insulin-dependent type 1 diabetes. This exocrine pancreatic deficit parallels the endocrine beta cell deficit, suggesting shared causes in type 1 diabetes development.
Area of Science:
- Endocrinology
- Gastroenterology
- Metabolic Diseases
Background:
- Diabetes mellitus is a complex metabolic disorder.
- The exocrine pancreas plays a crucial role in digestion.
- The relationship between endocrine and exocrine pancreatic function in diabetes is not fully understood.
Purpose of the Study:
- To investigate exocrine pancreatic function in patients with different types of diabetes mellitus.
- To explore the correlation between exocrine pancreatic enzymes and markers of diabetes control.
- To understand the potential link between exocrine pancreatic deficit and type 1 diabetes pathogenesis.
Main Methods:
- Measurement of serum immunoreactive trypsin concentration.
- Assay of pancreatic isoamylase activity.
- Correlation analysis with C peptide, glycosylated hemoglobin, insulin dosage, and age of onset.
Main Results:
- Exocrine pancreatic deficit was most pronounced in insulin-dependent diabetics.
- Intermediate deficit was observed in patients on sulfonylureas.
- No deficit was found in patients on biguanides or diet alone.
- A significant correlation was found between pancreatic enzymes and C peptide levels.
- Serum pancreatic enzyme levels were unrelated to glycosylated hemoglobin or insulin dosage.
- Low immunoreactive trypsin was noted at clinical onset in type 1 diabetics.
Conclusions:
- Exocrine pancreatic deficit in diabetes mellitus parallels endocrine beta cell deficit.
- Exocrine pancreatic dysfunction may occur concurrently with or precede type 1 diabetes onset.
- Shared pathogenic mechanisms may underlie impaired endocrine and exocrine pancreatic function in type 1 diabetes.
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