Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Distribution of cimetidine in postmortem tissues.

M J Berg, R K Lantz, J J Schentag

    Journal of Forensic Sciences
    |January 1, 1984
    PubMed
    Summary

    Cimetidine distributes unevenly across body tissues after absorption, concentrating most in the liver and kidneys. Its concentration in tissues decreases over time after death, especially in fat.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Elimination kinetics of cephapirin sodium in milk after an 8-day extended therapy program of daily intramammary infusion in healthy lactating Holstein-Friesian cows.

    Journal of dairy science·2013
    Same author

    Transduction of E13 murine neural precursor cells by non-immunogenic recombinant adeno-associated viruses induces major changes in neuronal phenotype.

    Neuroscience·2012
    Same author

    Prodynorphin processing by rat CNS fractions and purified enzymes: Formation of Dynorphin A 1-8 by sulfhydryl-activated carboxypeptidase and peptidyl dipeptidase.

    Neurochemistry international·2010
    Same author

    Separate metabolic pathways for Leu-enkephalin and Met-enkephalin-Arg(6)-Phe(7) degradation by rat striatal synaptosomal membranes.

    Neurochemistry international·2010
    Same author

    Evidence for conversion of N-Tyr-MIF-1 into MIF-1 by a specific brain aminopeptidase.

    Neurochemistry international·2010
    Same author

    Impact of organism species on microbial eradication and development of resistance in severe gram-negative pneumonia.

    Journal of chemotherapy (Florence, Italy)·2010

    Area of Science:

    • Pharmacokinetics
    • Drug Distribution
    • Toxicology

    Background:

    • Cimetidine is a widely used medication.
    • Understanding its distribution in various tissues is crucial for clinical and forensic applications.
    • Renal and liver dysfunction can significantly alter drug pharmacokinetics.

    Purpose of the Study:

    • To describe the postabsorptive distribution of cimetidine in human tissues.
    • To determine pharmacokinetic parameters and tissue: serum concentration ratios in patients with impaired renal and liver function.
    • To explore correlations between tissue distribution and postmortem intervals.

    Main Methods:

    • High-performance liquid chromatography (HPLC) was used for drug quantification.
    • Postmortem samples of cerebrospinal fluid, serum, and solid tissues were analyzed.
    • Pharmacokinetic parameters and tissue: serum (T:S) concentration ratios were calculated.

    Main Results:

    • The highest T:S ratios were observed in eliminating organs (liver and kidneys).
    • The lowest T:S ratios were found in adipose tissue (fat).
    • T:S ratios decreased as the time between death and autopsy increased.

    Conclusions:

    • Cimetidine distribution is organ-specific, with higher concentrations in organs responsible for elimination.
    • Postmortem redistribution and degradation affect cimetidine tissue concentrations over time.
    • These findings are relevant for interpreting cimetidine levels in forensic toxicology and clinical settings.

    Related Experiment Videos