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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
08:27

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

Published on: September 20, 2018

BAPS collective review: chronic inflammatory bowel disease

P A Raine

    Journal of Pediatric Surgery
    |February 1, 1984
    PubMed

    Insights

    Pediatric inflammatory bowel disease (IBD) cases, including Crohn's disease (CD) and ulcerative colitis (UC), showed significant growth issues and required surgery in over half of CD patients. Many experienced ongoing disease and complications, highlighting the chronic nature of pediatric IBD.

    Area of Science:

    • Pediatric Gastroenterology
    • Inflammatory Bowel Disease Research
    • Clinical Pediatrics

    Background:

    • Chronic inflammatory bowel disease (CIBD) presents unique challenges in children.
    • Early diagnosis and management are crucial for long-term outcomes in pediatric IBD.
    • Growth failure is a significant concern in pediatric Crohn's disease.

    Purpose of the Study:

    • To review the clinical characteristics, diagnostic methods, and outcomes of pediatric CIBD cases.
    • To analyze the surgical management and long-term disease course in children with Crohn's disease and ulcerative colitis.
    • To assess the impact of CIBD on growth and overall health in pediatric patients.

    Main Methods:

    • Retrospective review of 153 pediatric CIBD cases diagnosed between 1970-1979.
    • Analysis of diagnostic delays, presenting symptoms, and treatment interventions.
    • Evaluation of surgical outcomes, disease progression, and mortality rates at follow-up.

    Main Results:

    • Mean diagnosis ages were 10.5 years for Crohn's disease (CD) and 8.8 years for ulcerative colitis (UC), with diagnostic delays of 16.3 and 9.3 months, respectively.
    • Growth failure was prominent in CD (35.7% at follow-up).
    • Surgery was required in 57% of CD cases and 26% of UC cases, with high rates of reoperation and persistent disease (65% CD, 52% UC) at mean 6-year follow-up.

    Conclusions:

    • Pediatric CIBD, particularly CD, is associated with significant growth impairment and a substantial need for surgical intervention.
    • Delayed diagnosis and the chronic nature of the disease contribute to ongoing morbidity in children.
    • Effective long-term management strategies are essential for improving outcomes in pediatric IBD patients.

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