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Related Experiment Videos

Theophylline delays human sleep phase.

N Okudaira, D F Kripke, D J Mullaney

    Life Sciences
    |March 5, 1984
    PubMed
    Summary

    Theophylline, a xanthine, delayed sleep-wake cycles and sleepiness in healthy men. This suggests caffeine-containing foods and beverages may disrupt sleep and circadian rhythms.

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    Circadian phase in adults of contrasting ages.

    Chronobiology international·2005

    Area of Science:

    • Chronobiology
    • Pharmacology
    • Sleep Medicine

    Background:

    • Circadian rhythms regulate essential physiological processes, including sleep-wake cycles.
    • Xanthines, like theophylline, are commonly consumed and can affect biological rhythms.

    Purpose of the Study:

    • To investigate the effects of theophylline on 24-hour biological rhythms in healthy volunteers.
    • To assess the impact of theophylline on sleep-wake patterns and subjective sleepiness.

    Main Methods:

    • Administration of 250 mg of theophylline to twelve healthy male volunteers.
    • Monitoring of sleep-wake rhythms and subjective sleepiness over a 24-hour period.

    Main Results:

    • Theophylline administration resulted in a delay of sleep-wake rhythms.
    • Subjective sleepiness also showed a delayed pattern following theophylline ingestion.

    Conclusions:

    • Theophylline can alter circadian oscillators, leading to delayed sleep-wake cycles.
    • Dietary xanthines (e.g., in coffee, tea) may contribute to sleep disturbances.
    • Theophylline shows potential for therapeutic use in treating circadian rhythm disorders.

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