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Total body phosphorus in postmenopausal women.
Mineral and Electrolyte Metabolism
|January 1, 1984
Summary
Total body phosphorus (TBP) levels in postmenopausal women correlate with total body calcium (TBCa) and bone mineral content. TBP also associates with urinary phosphate and serum 1,25(OH)2D, indicating its role in bone health.
Area of Science:
- Bone Metabolism and Mineral Homeostasis
- Endocrinology
- Nuclear Medicine
Background:
- Menopause is associated with changes in bone mineral density.
- Phosphorus and calcium are critical minerals for skeletal health.
- Understanding mineral balance is key to managing postmenopausal bone loss.
Purpose of the Study:
- To investigate the relationship between total body phosphorus (TBP) and total body calcium (TBCa) in postmenopausal women.
- To explore associations between TBP, bone mineral content, and relevant biomarkers.
- To assess TBP status in relation to key hormonal and excretory factors.
Main Methods:
- Neutron activation analysis and whole body counting were used to measure TBP and TBCa.
- Bone mineral content of the distal radius was assessed.
- Serum and urinary markers, including phosphate and 1,25(OH)2D, were analyzed.
Main Results:
- Mean TBP was 395 g +/- 6.3 g in 82 postmenopausal women.
- TBP showed significant positive correlations with TBCa and distal radius bone mineral content.
- TBP was positively associated with urinary phosphate excretion and serum 1,25(OH)2D levels.
Conclusions:
- Total body phosphorus is closely linked with total body calcium and bone mineral density in postmenopausal women.
- TBP levels reflect aspects of mineral metabolism, including phosphate handling and vitamin D status.
- These findings highlight the interconnectedness of phosphorus, calcium, and vitamin D in maintaining skeletal integrity postmenopause.